This is a healthy volunteer study investigating the effect of balanced and unbalanced fluid infusions on serum electrolytes, osmolality and acid/base balance. In addition we are examining the role of balanced and unbalanced fluid infusions on renal perfusion and function.
Conditions
Interventions
Trade Name: Plasma-Lyte 148 (pH 7.4) Solution for Infusion
Product Name: Plasma-Lyte 148 (pH 7.4) Solution for Infusion
Product Code: PL 00116/0332
Pharmaceutical Form: Intravenous infusion
INN or Pro
Sponsors
University of Nottingham
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: HealthyMaleAged between 18 and 40 years Weight between 65 and 80kg Able to give informed consent Are the trial subjects under 18? Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Chronic medical conditions Any regular medications History of substance abuse Those individuals with a contraindication to MRI scanning: Metal implants Aneurysm clips Pacemaker or artificial heart valves Cochlear implants Claustrophobia Tattoos
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To determine the differential impact of balanced versus unbalanced fluid infusions on serum electrolyte, osmolality and acid base status.;Secondary Objective: To determine the differential impact of balanced versus unbalanced fluid infusion on renal function as measured by urinary NGAL and functional MRI.;Primary end point(s): To determine the differential impact of balanced versus unbalanced fluid infusion on serum electrolyte, osmolality and acid base status. The primary end point of each phase of this study will be a 6 mmol difference in serum chloride concentration after infusion of the balanced and unbalanced crystalloids and colloids. | — |
Countries
United Kingdom
Outcome results
None listed