alkohol dependence
Conditions
Interventions
Trade Name: Hydrocortison 10 mg Jenapharm
Product Name: Hydrocortison 10 mg Jenapharm
Pharmaceutical Form: Over encapsulated tablet
Pharmaceutical form of the placebo: Capsule*
Route of administration
Sponsors
Universitätsklinikum Schleswig-Holstein
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: alcohol dependence, abstention for 3 das minimum before entering the study, male subject, age in the rage 18 to 55 years Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: relevant psychiatric or organic comorbidities that might influence outcome and that might be negatively influenced by study medication e.g. depression, schizophrenia, obsessive comlusive disorder, anorexia, anxiety disorder, dementia, liver-cirrhosis, heart failure, epilepsy, dependence from other legal or illicit drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Improvement of the success of cue-exposure by administration of hydrocortisone or propranolol, i.e. stronger attenuation of craving for alcohol;Secondary Objective: 1. improvement of abstination rates 2. testing and improving emotianal memory function 3. improvement of sleep profile 4. normalisation of disturbed cortisol reactivity to stress 5. testing and improving glucose tolerance and insulin resistance;Primary end point(s): ending cue-exposure after 10 sessions maximum, last assesment of sleep and memory in the sleep laboratory after end of cue-exposure treatment. | — |
Countries
Germany
Outcome results
None listed