Acute pain to be tested in healthy volunteers
Conditions
Interventions
Trade Name: Ketanest-S
Product Name: S(+)-ketamine
Product Code: RVG22550
Pharmaceutical Form: Intravenous infusion
INN or Proposed INN: KETAMINE
CAS Number: 6740881
Other descriptive name: Ketanest-S
Sponsors
Leiden University Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: healthy volunteers, aged 18-45 years. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Obesity (BMI > 35); Presence of medical disease (heart-, lung-, liver-, kidney-, neurologic disease; diabetes m.; pyrosis; diaphragmatic hernia); Presence of psychiatric disease; History of chronic alcohol or illicit drug use;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: 1. The study the contribution of the NMDA receptor in the effect of methadon on pain rleief and respiratory depression 2. To study the contribution of the mu-opioid receptor in the effect of S(+)-ketamine on pain relief and respiratyory depression.;Secondary Objective: nonen;Primary end point(s): This study is aimed at quantifying the relative contribution of the two major receptor systems involved in S(+)-ketamine and methadone induced analgesia and side effects (respiratory depression, sedation, miosis). | — |
Countries
Netherlands
Outcome results
None listed