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Humoral and cellular immune response against tetanus and diphtheria following booster vaccination

Humoral and cellular immune response against tetanus and diphtheria following booster vaccination

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
EU CTR
Registry ID
EUCTR2009-011742-26-AT
Enrollment
Unknown
Registered
2009-04-02
Start date
2009-04-14
Completion date
Unknown
Last updated
2012-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

This study will analyze cellular and humoral immune responses after booster vaccination. Healthy adults are vaccinated against tetanus, diphtheria, pertussis and polio on a regular basis. This study will include individuals which are vaccinated according to the official Austrian recommendations. MedDRA version: 9.1 Level: LLT Classification code 10039244 Term: Routine vaccination MedDRA version: 9.1 Level: LLT Classification code 10054183 Term: Tetanus immunization MedDRA version: 9.1 Level:

Interventions

Trade Name: Boostrix Polio Pharmaceutical Form: Solution for injection Trade Name: Boostrix Pharmaceutical Form: Solution for injection

Sponsors

Institute for Biomedical Aging Research
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Signed informed consent form Group 1: Healthy adults aged 25-40 years Last vaccination against tetanus and diphtheria 10 years ago Group 2: Healthy adults older than 60 years Last vaccination against tetanus and diphtheria 5 years ago Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: acute illness (e.g. flu-like illness) chronic inflammatory disease (e.g. inflammatory bowl disease, multiple sclerosis) chronic hepatitis (HBV, HCV) or HIV transplant recipients persons who have recieved chemotherapy in the past persons under or immediatly after immunosuppressive therapy pregnant women participation in another clinical trial during the study

Design outcomes

Primary

MeasureTime frame
Main Objective: To analyze whether the immune response against tetanus and diphtheria is different in young adults vaccinated 10 years after the last vaccination compared to elderly individuals vaccinated 5 years after the last vaccination.;Secondary Objective: To identify predictive markers for the success of the booster vaccination.;Primary end point(s): Quantification of the immune response following booster vaccination 28 days after vaccination—

Countries

Austria

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026