Myocardial infarction MedDRA version: 9.1 Level: LLT Classification code 10000929 Term: Acute myocardial infarction, unspecified site, episode of care unspecified
Conditions
Sponsors
University of Dundee
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Confirmed diagnosis of myocardial infarction, based on the recently published Universal criteria for diagnosis of myocardial infarction (Troponin T >0.02 plus one of: Symptoms consistent with myocardial ischaemia, ECG changes consistent with myocardial ischaemia, new Q waves on ECG, new regional wall motion abnormality or evidence of new loss of viable myocardium on imaging. Admitted to Tayside Hospitals within 1 week of index event Age>18 years Minimum of 6 weeks after index event Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Estimated GFR 2.60 mmol/L LFTs >3x upper limit of normal Already taking vitamin D supplements. Consumption of fish oils will not be a contraindication to enrolment Known metastatic malignancy History of renal calculi or sarcoidosis Supine systolic BP <80 mmHg Pregnant, lactating, or of childbearing age and not taking reliable contraception Unable to give written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Does high dose oral vitamin D3 improve endothelial function in patients post myocardial infarction?;Secondary Objective: Does high dose oral vitamin D3 improve soluble markers of vascular health in patients post myocardial infarction? Does high dose oral vitamin D3 reduce blood pressure and cholesterol in patients post myocardial infarction? ;Primary end point(s): Change in endothelial function between baseline and six months, measured by the EndoPAT system | — |
Countries
United Kingdom
Outcome results
None listed