critically ill patients hospitalised in inetnsive care unit MedDRA version: 13.1 Level: PT Classification code 10022519 Term: Intensive care System Organ Class: 10042613 - Surgical and medical procedures
Conditions
Interventions
Trade Name: OMNIPAQUE
Product Name: OMNIPAQUE
Pharmaceutical Form: Injection
INN or Proposed INN: iohexol
Sponsors
CHU Saint-Etienne
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - 18 to 75 years - patients hospitalized in intensive care unit for at least 72 h with the admission score IGS> 2 - patient intubated-ventilated and stable in respiratory - haemodynamically stable patient - patient with indwelling catheter and central venous catheter, and peripheral catheter - last rate of plasma creatinine =65 years) F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: - allergic patient - patients with severe hepatic impairment defined as a TP spontaneously below 50% Patients with a history of dysthyroidism - Patient requiring treatment with trimethoprim, cimetidine or corticosteroid (inflammatory dose) - Pregnant or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Secondary Objective: to evaluate urinary biomarkers NGAL, IL 8 et KIM-1 in relation to a gold standard method of glomerular filtration rate measurement;Primary end point(s): - Area under the curve ROC for a threshold of iohexol clearance of 60 ml / min of cystatin C and plasma creatinin.;Main Objective: to evaluate the diagnostic performance of cystatin C to detect renal failure in critically ill patients, the true level of renal function impairment being determined by a gold standard method of glomerular filtration rate measurement. | — |
Countries
France
Outcome results
None listed