Radical oxygen activity in leukocytes.
Conditions
Interventions
Trade Name: Pinex
Product Name: Paracetamol
Pharmaceutical Form: Tablet
CAS Number: 103-90-2
Trade Name: Ibumetin
Product Name: Ibuprofen
Pharmaceutical Form: Tablet
CAS Number: 15687-27-1
Sponsors
Section of dental pharmacology and pharmacotherapy, ICO, University of Oslo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Fasting, healthy, adult volunteers, ASA classification I (age 18-35 years) of both genders taking no NSAID on a regular basis. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: The aim primary of this study is to investigate the capacity of leukocytes to respond with ROS synthesis upon a defined in vitro stimulus, PMA, after exposure to ibuprofen and paracetamol in vivo.;Secondary Objective: A second aim is to examine if platelet activation status is affected by the respective drugs.;Primary end point(s): ROS-activity i leukocytes | — |
Countries
Norway
Outcome results
None listed