Memory performance under stressful conditions
Conditions
Interventions
Trade Name: Spironolactone
Product Name: Spironolactone
Product Code: RVG 18639
Pharmaceutical Form: Tablet
INN or Proposed INN: SPIRONOLACTONE
CAS Number: 52017
Concentration unit: mg milligram(s)
Co
Sponsors
Maastricht University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: - Healthy subjects - Age 18 - 35 - Male Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: - Suffering from cardiovascular diseases, severe physical illness, hypertension current of lifetime psychopathology or endocrine disorders. - being on medication known to affect HPA-axis functioning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: The primary objective of this study is to investigate the role of the mineralocorticoid receptor (MR) in memory performance under stressful and non-stressful conditions in humans by administering the MR antagonist Spironolactone.;Secondary Objective: This study will also yield insights into whether the clinical use of Spironolactone as a treatment drug for heart failure and hypertension may yield unwanted side effects on memory performance. ;Primary end point(s): - Memory performance, being defined as the number of words to be recalled after 24 hours. | — |
Countries
Netherlands
Outcome results
None listed