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STUDY ON PLEIOTROPE EFFECTS OF HIGH DOSE STATIN IN THE COMMENCEMENT OF INFLAMMATORY PROCESSES IN THE ABDOMINAL AORTIC ANEURYSM WALL. - SPITFIRE II

STUDY ON PLEIOTROPE EFFECTS OF HIGH DOSE STATIN IN THE COMMENCEMENT OF INFLAMMATORY PROCESSES IN THE ABDOMINAL AORTIC ANEURYSM WALL. - SPITFIRE II

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
EU CTR
Registry ID
EUCTR2008-007468-41-NL
Enrollment
Unknown
Registered
2009-05-12
Start date
2009-05-11
Completion date
Unknown
Last updated
2012-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdomina

Interventions

Trade Name: Simvastatin Product Name: Simvastatin Pharmaceutical Form: Tablet INN or Proposed INN: Simvastatin CAS Number: 79902-63-9 Concentration unit: mg milligram(s) Concentration type: equal Conc

Sponsors

LUMC
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patienten awaiting elective, open aneurysm repair Informed consent Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Known liver or kidney dysfunction Intolerability of statin treatment

Design outcomes

Primary

MeasureTime frame
Main Objective: To test whether high dose simvastatin quenches vascular inflammation in the abdominal aortic aneurysm;Secondary Objective: ;Primary end point(s): Markers of vascular inflammation with particular focus on IL-6 and 8 signalling—

Countries

Netherlands

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026