Obsessive-compulsive disorder (OCD) MedDRA version: 9.1 Level: LLT Classification code 10029898 Term: Obsessive-compulsive disorder
Conditions
Interventions
Trade Name: Cycloserine
Pharmaceutical Form: Capsule*
Other descriptive name: D-cycloserine
Concentration unit: mg milligram(s)
Concentration type: equal
Concentration number: 50-
Pharmaceutical form
Sponsors
King's College London (Institute of Pyschiatry)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: i) DSM-IV diagnosis of OCD ii) Age 12-18 iii) Referred to the National and Specialist OCD clinic at Maudsley Hospital iv) If on medication, that should be stable for 12 weeks, and not be changed during the course of the trial v) Provision of written informed consent (patient and carer) Are the trial subjects under 18? yes Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: i) Current diagnosis of psychosis, current alcohol or substance abuse/dependence ii) English too poor to engage in treatment iii) Severe disabling neurological disorder iv) Medical contraindication to cycloserine, including epilepsy and porphyria v) A diagnosed global learning disability or pervasive developmental disorder vi) Characteristics interfering with completion of treatment eg life-threatening or unstable medical illness vii) Pregnancy viii) Not suitable for CBT (selective mutism, lack of insight or motivation to change)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To establish the clinical effectiveness of D-cycloserine (DCS) augmented cognitive behavioural therapy (CBT) for children and adolescents with OCD, and whether that affects the speed of recovery. ;Secondary Objective: To determine which processes in fear extinction are modified by DCS, and when this occurs, during exposure therapy for OCD in young people. ;Primary end point(s): Childrens' Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) | — |
Countries
United Kingdom
Outcome results
None listed