none
Conditions
Sponsors
UZLeuven
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteers (18-45 years) who have no bowel symptoms and who are in good general health are eligible for the study. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: • They have relevant underlying disease (cardia, pulmonary, metabolic, kidney or liver disease, …) • They have a history of esophageal or gastric surgery, or recurrent or intermittent upper gastrointestinal symptoms (upper abdominal pain, nausea, vomiting, bothersome fullness or early satiation, heartburn, regurgitation,…) • They have a history of allergy to several types of drugs or food. • They have ever been treated for depression • They use cannabinoids. • There is a possibility of becoming pregnant during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To investigate a potential contribution of endocannabinoid pathways, we want to study gastric accommodation and nutrient tolerance after pretreatment with rimonabant, a blocker of the CB1 receptor used clinically in the treatment of obesity. ;Secondary Objective: /;Primary end point(s): Dual primary endpoint: 1) size of the meal-induced gastric accommodation 2) liquid nutrient tolerance to reach maximum satiation | — |
Countries
Belgium
Outcome results
None listed