idiopathic chronic cough, defined as cough with no identifiable cause and which has been present for at least 2 monhs. MedDRA version: 9.1 Level: LLT Classification code 10011224 Term: Cough
Conditions
Interventions
Trade Name: Zithromx
Product Name: Zithromax
Pharmaceutical Form: Capsule*
Pharmaceutical form of the placebo: Capsule*
Route of adminis
Sponsors
The University of Nottingham
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adults with cough for greater than 2 months after exclusion of other common causes of cough (asthma, eosinophilic bronchitis, gastroeosophogeal reflux and upper airway syndrome). Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Active smoking or smoking history in excess of 20 pack years. Non-idiopathic cough or other major co-morbidity including abnormal liver function tests Taking medication known to interact with azithromycin (cylcosporin, terfenadine, theophylline and warfarin).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To determine if macrolide antibiotics are effective in idiopathic chronic cough;Secondary Objective: Provide information on the pathology, exhaled nitric oxide concentration and Chlamydia and Mycoplasma status in patients with idiopathic chronic cough.;Primary end point(s): The difference in the Leicester Cough Questionnaire score between active and placebo groups. | — |
Countries
United Kingdom
Outcome results
None listed