A randomised, double blinded, crossover study of the influence of Metoprolol on exercise induced elevation of catecholamines in healthy subjects. - MEXICHO

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2008-001908-23-DK

Enrollment

Registered

2008-06-11

Start date

2008-06-20

Completion date

Unknown

Last updated

2021-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The medical condition to be investigated is heart failure, but this specific study is made on healthy volunteers to investigate the influence of metoprolol on exercise induced elevation of catecholamines.

Interventions

Trade Name: Selo-Zok Pharmaceutical Form: Tablet INN or Proposed INN: METOPROLOL SUCCINATE CAS Number: 98418474 Concentration unit: mg milligram(s) Concentration type: equal Concentration number: 100-

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Male, age 20-30 years, non-smoker, BMI 20-25, no chronic diseases including asthma bronchiale and cardiovascular diseases of any kind. No injuries of muscoloskeleton, that prevents participants in performing a full maximal cardiopulmonary test. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Following medical products during investigational periode: asthma medication, heart medication, antihistamines, antipsycotics, NSAIDs, rifampicin, chinidine, glukocorticoides, abuse of any kind. Allergy and/or intolerance to metoprololsuccinate. Allergy to lactose. Abnormal ECG. Abnormal bloodsugar according to standards.

Design outcomes

Primary

Measure	Time frame
Main Objective: The main objective of this trial is to investigate the influence of metoprolol on exercise induced catecholamine response. It is also a main objective to investigate the possible influence of certain single nukleotide polymorphisms in candidate genes on this alteration in catecholamin response due to metoprolol treatment. ;Secondary Objective: Secondary objectives are alterations in blood pressure and heart rate response. ;Primary end point(s): Alteration of exercise induced catecholamine response (epinephrine, norepinephrine) due to treatment with metroprolsuccinate.	—

Measure

Time frame

Main Objective: The main objective of this trial is to investigate the influence of metoprolol on exercise induced catecholamine response. It is also a main objective to investigate the possible influence of certain single nukleotide polymorphisms in candidate genes on this alteration in catecholamin response due to metoprolol treatment. ;Secondary Objective: Secondary objectives are alterations in blood pressure and heart rate response. ;Primary end point(s): Alteration of exercise induced catecholamine response (epinephrine, norepinephrine) due to treatment with metroprolsuccinate.

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Countries

Denmark

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026