A Comparison of the Post-operative analgesic effects of Propofol anaesthesia with Sevoflurane anaesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2008-001052-48-IE

Enrollment

Registered

2008-03-03

Start date

2008-06-10

Completion date

Unknown

Last updated

2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute post-operative pain MedDRA version: 9.1 Level: LLT Classification code 10066714 Term: Acute pain MedDRA version: 9.1 Level: LLT Classification code 10036286 Term: Post-operative pain

Interventions

Trade Name: Diprivan Product Name: Diprivan Product Code: Propofol Pharmaceutical Form: Intravenous infusion INN or Proposed INN: PROPOFOL CAS Number: 2078548 Current Sponsor code: Propofol-1 Other de

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologist classification I and II patients; aged over 18 years undergoing laparoscopic day case surgery. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Chronic pain states; known allergies or contraindications to the study medications; lack of informed consent; currently pregnant; currently breast feeding

Design outcomes

Primary

Measure	Time frame
Main Objective: To determine if intravenous propofol anaesthesia compared to inhalational sevoflurane has a postoperative analgesic effect in the immediate postoperative period.;Secondary Objective: To determine if intravenous propofol anaesthesia has a better quality of recovery compared to inhalational sevoflurane.;Primary end point(s): Pain score 0-10 measured on a visual analogue scale. Cumulative morphine consumption. Sedation score Quality of recovery score (QoR-9 and QoR-40 scores)	—

Measure

Time frame

Main Objective: To determine if intravenous propofol anaesthesia compared to inhalational sevoflurane has a postoperative analgesic effect in the immediate postoperative period.;Secondary Objective: To determine if intravenous propofol anaesthesia has a better quality of recovery compared to inhalational sevoflurane.;Primary end point(s): Pain score 0-10 measured on a visual analogue scale. Cumulative morphine consumption. Sedation score Quality of recovery score (QoR-9 and QoR-40 scores)

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Countries

Ireland

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026