To be investigated is the anti-inflammatory and anti-oedematous effect of methylprednisolone on the postoperative sequelae after surgical removal of lower third molars. 16 healthy patients will undergo surgical removal of bilateral symmetrically placed lower third molars. Each patient will be administered 1mg methylprednisolone per kg weight 1 hour prior to the surgery on one side, and a placebo containing lactose an the other side on a random basis.
Conditions
Interventions
Product Name: Methylprednisolon
Product Code: MP
Pharmaceutical Form: Capsule, hard
Pharmaceutical form of the placebo: Capsule, hard
Route of administration of the placebo: Oral use
Sponsors
Univ.-Prof. DDr. Norbert Jakse, Universitätszahnklinik Graz, Dep. f. Orale Chirurgie u. Röntgenologi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: +male and female healthy patients between the age of 18 and 40 +lower third molars which have to be removed surgically +impacted lower third molars +axis: vertical or mesial tilted Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: -preagnancy and lactation -patients with an affection of the Temporo-mandibular joint -presurgical inflammation or pain in the area of the lower third molars -diseases which are a contraindication for the use of one of the drugs to be taken -incompatibility to one of the drugs to be taken or lactose -severe diseases which are a contraindication to a surgical removal of third molars -current participation in other pharmacological studies -when a complicated removal of the lower third molar can be anticipated because of its position in the jaw
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To find out if methylprednisolone reduces the postsurgical trismus, pain and swelling of the cheek after surgical removal of lower third molars.;Secondary Objective: ;Primary end point(s): | — |
Countries
Austria
Outcome results
None listed