alcohol abuse MedDRA version: 9.1 Level: LLT Classification code 10001584 Term: Alcohol abuse
Conditions
Interventions
Trade Name: Centrafarm
Product Code: RVG 55618
Pharmaceutical Form: Tablet
INN or Proposed INN: PROPRANOLOL
CAS Number: 525666
Concentration unit: mg milligram(s)
Concentration type: equal
Concentrat
Sponsors
Maastricht University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: males age >= 18 recent history of heavy alcohol use 15–50 European standard drinks per week (European standard drinks contain about 10 g pure alcohol) Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: No history of treatment for addiction. No use of medication that may interact with alcohol. No contra-indications for propranolol: sick-sinussyndrome, second- and thirddegree atrioventriculair-block, hypotension, cardiogene shock, clinically relevant sinusbradycardie, asthma and othetr obstructive longdiseases or untreated hartfailure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Weakening of previous learned positive associations with alcohol by propranolol administered immediately upon retrieval of these associative memories.;Secondary Objective: ;Primary end point(s): 1. scores on computertasks, comparison of scores from placebo and propranolol treatment. 2. subjective craving-scores using VAS-questionaires after completion of the computertasks | — |
Countries
Netherlands
Outcome results
None listed