pain
Conditions
Interventions
Product Name: Dexmedetomidine
Pharmaceutical Form: Intravenous infusion
Pharmaceutical form of the placebo: Intravenous infusion
Route of administration of the placebo: Intravenous use
Trade Name: Ke
Sponsors
Karolinska University Hospital Huddinge, Department of Anaesthesiology and Intensive Care
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteers over 18 years old Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Intake of substances that influence the effects or side-effects of dexmedetomidine or ketamine. Pain at the beginning of the trial (more than 0/10 on the visual analog scale, VAS).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To examine the effect of the combination of low doses dexmedetomidine and ketamine in relation to the effects of one of the drugs alone on experimental pain.;Secondary Objective: To examine if the combination of dexmedetomidine and ketamine influence ventilatory funktion and if the combination of these two drugs reduce the circulatory and sensorial sideeffects in relation to the sideeffects of the drugs given alone.;Primary end point(s): Pain (VAS), heartrate, blood pressure, respiratory rate, percutane oxygen saturation, mental funktion | — |
Countries
Sweden
Outcome results
None listed