This is a volunteer study in healthy volunteers. Pain research, reversal of hyperalgesia by IMP is studied.
Conditions
Sponsors
Department of Anaesthesie, General Intensive Care and Pain Therapy, Medical University of Vienna
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Men or women, aged between 19 and 40 years Body mass index between 15th and 85th percentile Normal findings in the medical history and physical examination Drug free for 1 week prior to the study day Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Pregnancy any disease ongoing pain older than 40 years old
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To study the reversal of established hyperalgesia. The main outcome variable will be: area of pin prick hyperalgesia.;Primary end point(s): Area of pin prick hyperalgesia 6 hours after stop of IMP;Secondary Objective: To study the reversal effect on additional outcome variables for mechanical hyperalgesia will be: stimulus-response (SR)-function to a set of modified rigid von Frey filaments (8 -512 mN), area of dynamic allodynia to brush and SR-function to dynamic mechanical stimuli. Pain immediately after injection and heat pain threshold within the area of mechanical hyperalgesia will serve as additional outcome variables. | — |
Countries
Austria
Outcome results
None listed