Symptomatic carotid artery stenosis MedDRA version: 9.1 Level: LLT Classification code 10007687 Term: Carotid artery stenosis
Conditions
Interventions
Trade Name: Plavix
Product Name: Clopidogrel
Pharmaceutical Form: Tablet
Trade Name: Persantin
Product Name: Dipyridamole
Sponsors
St Georges Healthcare NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with greater than or equal to 50% carotid artery stenosis AND symptoms of transient ischaemic attack or stroke within the last month. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: 1. antiplatelet/antithrombotic medication other than aspirin (although low does prophylactic subcutaneous heparin for DVT prophylaxis will be allowed) 2. patients with prosthetic heart valves who have gaseous embolic signals. 3. patients in who clopidogrel or dipyridamole are contraindicated. 4. If carotid endarterectomy is planned during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Is clopidogrel plus aspirin, or dipyridamole slow release plus aspirin, a better combination in preventing embolisation in recently symptomatic large artery atherosclerotic disease?;Secondary Objective: ;Primary end point(s): Number of embolic signals during transcranial Doppler recording from ipsilateral middle cerebral artery performed at 48 hours after study entry | — |
Countries
United Kingdom
Outcome results
None listed