A pilot for a case control study to evaluate the effects of High Dosage Oxygen Therapy as an adjunct to an established program of physiotherapy and rehabilitation for sub acute soft tissue knee conditions in a sample of police officers admitted for rehabilitation to the Police Rehabilitation Centre, Flint House. - High Dosage Oxygen Therapy as an adjunct to physiotherapy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2007-002653-23-GB

Enrollment

Registered

2007-07-31

Start date

2008-09-02

Completion date

Unknown

Last updated

2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sub acute soft tissue injuries to the knee . MedDRA version: 9.1 Level: LLT Classification code 10041292 Term: Soft tissue injury NOS

Interventions

Trade Name: Medical Liquid Oxygen Product Name: Oxygen (refrigerated) Pharmaceutical Form: Inhalation gas

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A sample of police officers (of either gender) referred to the Police Rehabilitation Centre. for a standard 12 day rehabilitation programme for the following conditions: sub acute soft tissue injuries to the knee (i.e. injuries to the knee ligaments, meniscus, or post surgery for knee arthroscopy, ligament repair). For the purposes of the study 'sub acute' will be defined as 3 weeks to 3 months post injury onset or post surgery. The participants must be adults and able to give informed consent. The participants must have no pre existing condition which will exclude them from undertaking Hyperbaric Treatment (they will medically screened prior to the administration of the first treatment and appropriately referred by a qualified medical practitioner). Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Chronic Knee Conditions (see definition of sub acute). Ill defined knee conditions (e.g.. internal derrangement of the knee joint (IDKJ) or 'anterior knee pain') Rheumatoid disease Repeated knee injuries Peripheral vascular disease Referred pain from the hip, pelvis or spine. History of pneumothorax Heart condition Trauma to the chest Upper respiraory tract infection Patients who are febrile Pregnancy.

Design outcomes

Primary

Measure	Time frame
Main Objective: To gain data, as part of a cost benefit analysis prior to purchasing a Hyperbaric Chamber, to evaluate the role of High Dosage Oxygen Therapy (HDOT) as an adjunct to standard physiotherapy in the rehabilitation of soft tissue injuries.;Secondary Objective: To estimate the sample size required for a major study (using a Power Calculation);Primary end point(s): Measurement of functional ability and validated survey	—

Measure

Time frame

Main Objective: To gain data, as part of a cost benefit analysis prior to purchasing a Hyperbaric Chamber, to evaluate the role of High Dosage Oxygen Therapy (HDOT) as an adjunct to standard physiotherapy in the rehabilitation of soft tissue injuries.;Secondary Objective: To estimate the sample size required for a major study (using a Power Calculation);Primary end point(s): Measurement of functional ability and validated survey

—

Countries

United Kingdom

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026