glaucoma patients
Conditions
Sponsors
University of Leuven
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - individuals over 18 years old - willing to sign an informed consent and able to comply with the requirements of the examination Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: - history of ocular trauma or eye disease that cannot be accounted for by refractive error - best refracted visual acuity less than -1.18 on the logarithmic EDTRS-scale in the study eye - contra-indications for the use of simvastatin or acetazolamide - already on statin therapy or need for urgent statin therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: to look at the ocular bloodflow after simvastatine intake;Secondary Objective: ;Primary end point(s): Blood flow velocities will be measured in the ophthalmic artery (OA), the central retinal artery (CRA), and of the temporal and nasal short posterior ciliary arteries (TPCA, NPCA) using CDI. The following parameters analyzed: peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive indices (RI). Moreover, to evaluate the elasticity of the blood vessels, the difference between the PSV and the dicrotic notch will be measured. | — |
Countries
Belgium
Outcome results
None listed