Influence of insulin therapy in non-diabetic patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease (COPD) - insulin in COPD

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2007-000666-20-GB

Enrollment

371

Registered

2007-04-17

Start date

2007-06-14

Completion date

Unknown

Last updated

2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease (COPD) MedDRA version: 9.1 Level: LLT Classification code 10009033 Term: Chronic obstructive pulmonary disease

Interventions

Trade Name: Apidra insulin Pharmaceutical Form: Solution for injection INN or Proposed INN: insulin glulisine CAS Number: 207748-29-6 Cu

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are NOT diabetic, admitted with COPD who are likely to be prescribed corticosteroids as part of usual care with an admission glucose level (before steroids) between 6.1 and 11.1 mmol/l. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Patients with diabetes mellitus Patients who are nil by mouth. Patients with severe co-morbid disease with an anticipated life expectancy of < 6 months. Patients who are unable to provide informed consent. Age <18 years.

Design outcomes

Primary

Measure	Time frame
Main Objective: To determine if the effect of treating hyperglycaemia in patients admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease can reduce their readmission rate to hospital. ;Secondary Objective: Does the use of insulin in COPD exacerbations reduce in-patient length of stay and mortality?;Primary end point(s): The primary end-point of interest will be rate of readmission to hospital within 90 days.	—

Measure

Time frame

Main Objective: To determine if the effect of treating hyperglycaemia in patients admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease can reduce their readmission rate to hospital. ;Secondary Objective: Does the use of insulin in COPD exacerbations reduce in-patient length of stay and mortality?;Primary end point(s): The primary end-point of interest will be rate of readmission to hospital within 90 days.

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Countries

United Kingdom

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026