At birth, a VLBW infant is abruptly disconnected from the ideal source of parenteral nutrition - the placenta. If the goal of post-natal nutrition in the VLBW infant is to mimic in utero nutrition. The VLBW infant should be immediately placed on balanced parenteral nutrition. In current praxis parenteral nutrition used to be delayed for several days. MedDRA version: 9.1 Level: LLT Classification code 10063258 Term: Amino acid level
Conditions
Interventions
Trade Name: Amninopäd® 10%
Pharmaceutical Form: Intravenous infusion
Other descriptive name: aminoacidmix
Concentration unit: g/l gram(s)/litre
Concentration type: equal
Concentration number: 100 g/l-
Sponsors
University Childrin's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Preterm infant with a birth weight below 2000g Are the trial subjects under 18? yes Number of subjects for this age range: F.1.2 Adults (18-64 years) no F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Inborn error of metabolism which requires a reduction of amino acid intake
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Incidence of metabolic acidosis due to hyperamonemia with intake of 1.5 g/kg/d and increase to 3,5 g/kg/d amino acid from day 1 to day 5 of life in comparison to 3.5 g/kg/d amino acid at day 1 of life.;Secondary Objective: Comparison of extracellular water, total body water, energy expenditure, and protein and amino acid metabolism in the low and high amino acid group.. Examination of growth (weight gain, linear and head growth) until hospital discharge.;Primary end point(s): base excess due to hyperammonemia | — |
Countries
Germany
Outcome results
None listed