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The effect of pre-operative Ramipril treatment on vascular inflammation in the abdominal aneurysm

The effect of pre-operative Ramipril treatment on vascular inflammation in the abdominal aneurysm

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
EU CTR
Registry ID
EUCTR2006-006105-86-NL
Enrollment
Unknown
Registered
2006-12-12
Start date
2007-05-11
Completion date
Unknown
Last updated
2012-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

An aneurysm of the abdominal aorta MedDRA version: 8.1 Level: LLT Classification code 10002882 Term: Aortic aneurysm

Interventions

Trade Name: Ramipril Product Name: Ramipril Pharmaceutical Form: Capsule* INN or Proposed INN: RAMIPRIL CAS Number: 87333195 Current Sponsor code: Tritace Concentration unit: mg milligram(s) Concentra

Sponsors

LUMC
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Elective aneurysm repair operation Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Hypotension Renal artery stenosis

Design outcomes

Primary

MeasureTime frame
Main Objective: To test whether Ramipril, via its presumed effects on NFkB activation, reduces vascular inflammation in the abdominal aneurysm.;Secondary Objective: Te test whether Ramipril reduces protease activity in the abdominal aneurysm;Primary end point(s): NFkB activation in the aortic wall IL-6 and 8 expression in the aortic wall—

Countries

Netherlands

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026