How lidocaine is metabolised in the skin
Conditions
Interventions
Trade Name: Xylocain
Product Name: Xylocain
Pharmaceutical Form: Ointment
Sponsors
Danish University of Pharmaceutical Sciences
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: male, age 18-40, healthy Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: known skin or liver disease, known allergy to lidocaine, the use of drugs in the week before the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To investigate the dermal cytochrome P450 metabolism of lidocaine in human skin (At undersøge cytochrom P450 metabolismen af lidokain i huden);Secondary Objective: To evaluate if the mouse can be used as an appropriate model for future studies of dermal cytochrome P450 metabolism. (At vurdere om musen kan anvendes som modeldyr ved fremtidige dermale metabolisme studier);Primary end point(s): 2 hours expore of lidcaine ointment to the skin | — |
Countries
Denmark
Outcome results
None listed