Septic shock
Conditions
Interventions
Trade Name: Noradrenaline (Norepinephrine) 1:1000 or Levophed
Pharmaceutical Form: Solution for infusion
Sponsors
Queen Mary's School of Medicine & Dentistry, University of London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients admitted to intensive care at Barts and The London NHS Trust who require vasopressor infusion (noradrenaline) for the treatment of septic shock Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Refusal of patient’s consent or relative’s assent Cconcurrent lithium therapy Acute myocardial ischaemia Acute arrhythmias Pregnancy Weight less than 40 kg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Comparison of sublingual microvascular flow index at different mean arterial pressures;Primary end point(s): To assess the effects of different mean arterial pressure end-points for noradrenaline dose on microvascular flow using SDF imaging in addition to global cardiovascular and biochemical measurements in patients suffering from septic shock;Secondary Objective: Comparison of tissue PO2 at different mean arterial pressures Comparison of cutaneous red cell flux and velocity at different mean arterial pressures Comparison of cutaneous temperature at different mean arterial pressures Comparison of cardiac index at different mean arterial pressures Comparison of serum lactate and base excess at different mean arterial pressures Comparison of urine output at different mean arterial pressures | — |
Countries
United Kingdom
Outcome results
None listed