1. Postoperative pain and hyperalgesia following laparotomy for colorectal surgery 2. Chronic pain following laparotomy for colorectal surgery
Conditions
Interventions
Trade Name: Catapres
Pharmaceutical Form: Injection*
Trade Name: Generic bupivacaine
Product Name: Bupivacaine 0.25%
Pharmaceutical For
Sponsors
R&D Department, Box 146, Addenbrooke's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing laparotomy through vertical midline incision for colonic pathology and requiring an epidural catheter for perioperative analgesia, ASA physical status I-III, between 18-80 years of age. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Previous abdominal surgery, renal or hepatic dysfunction, inability to understand or comply with the study protocol, allergy to any of the study drugs, impossible to place an epidural catheter, malfunctioning epidural catheter.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Efficacy of clonidine in reduction in area of hyperalgesia around the incision following laparotomy;Secondary Objective: Efficacy of clonidine in treatment of acute and chronic pain;Primary end point(s): Reduction in area of post-incisional hyperalgesia on the third postoperative day following laparotomy for colorectal surgery. | — |
Countries
United Kingdom
Outcome results
None listed