Metabolic Modulation as treatment of acute heart failure in patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2006-004485-14-DK

Enrollment

Registered

2006-12-07

Start date

2007-01-18

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute decompensated heart failure MedDRA version: 8.1 Level: LLT Classification code 10000803 Term: Acute heart failure

Interventions

Trade Name: olbetam Product Name: acipimox Pharmaceutical Form: Capsule* INN or Proposed INN: ACIPIMOX CAS Number: 51037300 Concentration unit: mg milligram(s) Concentration type: equal Concentration

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: seriuos Acute heart failure Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Age 85, Recent myocardial infarction (<6 weeks), renal failure, Insulintreated diabetes, Gastric Ulcer, pregnancy

Design outcomes

Primary

Measure	Time frame
Main Objective: To test the the potential of and the metabolic consequences of acipimox-treatment in acute heart failure and the effects on central hemodynamics;Secondary Objective: to evaluate Non invasive cardiac output measuerments in acute decompensated heartfailure ;Primary end point(s): myocardial glucose- and free fatty acid-extraction Invasive cardiac index Pulmonary capillary wedge pressure (PCWP)	—

Measure

Time frame

Main Objective: To test the the potential of and the metabolic consequences of acipimox-treatment in acute heart failure and the effects on central hemodynamics;Secondary Objective: to evaluate Non invasive cardiac output measuerments in acute decompensated heartfailure ;Primary end point(s): myocardial glucose- and free fatty acid-extraction Invasive cardiac index Pulmonary capillary wedge pressure (PCWP)

—

Countries

Denmark

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026