Prevention of postoperative delirium with donepezil

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2006-004434-32-DE

Enrollment

400

Registered

2007-02-20

Start date

2007-02-06

Completion date

Unknown

Last updated

2012-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium

Interventions

Trade Name: Arizept Product Code: AN06DA02 Pharmaceutical Form: Tablet INN or Proposed INN: donepezilhydrochlorid Other descriptive name: BNAG, E2020 (Eisai, J) Concentration unit: mg milligram(s) Con

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are 70 years and older, who are admitted for elective hip or knee joint replacement ASA-classification I - III Informed consent Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Evidence of delirium Sensory impairment Hypersensitivity to donepezilhydrochlorid (DPZ) or piperidine derivates or contraindications to the use of DPZ bradycardia asthma COPD gastric ulcer participation in a clinical trial

Design outcomes

Primary

Measure	Time frame
Main Objective: To investigate, if perioperative treatment with donepezil reduces the incidence of postoperative delirium in patients older than 69 years with elective knee- or hip joint replacement.;Secondary Objective: To investigate, if perioperative treatment with donepezil influences - severity and duration of postoperative delirium - degree and duration of postoperative delirium - length of hospital stay - management of general anaesthesia;Primary end point(s): Incidence of postoperative delirium accotding to CAM (Confusion assessment method) criteria	—

Measure

Time frame

Main Objective: To investigate, if perioperative treatment with donepezil reduces the incidence of postoperative delirium in patients older than 69 years with elective knee- or hip joint replacement.;Secondary Objective: To investigate, if perioperative treatment with donepezil influences - severity and duration of postoperative delirium - degree and duration of postoperative delirium - length of hospital stay - management of general anaesthesia;Primary end point(s): Incidence of postoperative delirium accotding to CAM (Confusion assessment method) criteria

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Countries

Germany

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026