Postoperative nausea and vomiting (PONV) and postoperative recovery time.
Conditions
Interventions
Trade Name: Propofol-Lipuro
Pharmaceutical Form: Intravenous infusion
Trade Name: Forene
Pharmaceutical Form: Inhalation vapour, liquid
Sponsors
University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: This study will include patients scheduled for elective intracranial surgery, positioned with Mayfield head-rest and with an expected anesthesia time of at least 4 hours. Patients in the age of 18-75 with ASA physical status ?-?? will be included in the study. Approval by the local ethics committee and written informed consent will be obtained from each patient. The patients will be under betamethason treatment, due to the intracranial process. The number of patients that this study will include is 80. The patients will be randomly assigned to one of two groups: Group C, (Control) will receive inhalation anesthesia with isoflurane during the whole procedure. Group P (Propofol) will receive isoflurane until the surgeon starts to close the dura, then the isoflurane will be discontinued and propofol infusion will be used instead during the remainder of surgery. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Criteria of exclusion will be severe cardiac infarction or if the condition of the patient demands another type of anesthesia than that described above.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Neurosurgery is normally associated with a high incidence of postoperative nausea and vomiting (PONV), especially in patients undergoing craniotomy for intracranial surgery, positioned in Mayfield head-rest and with duration of anesthesia for 4 hours or more. Balanced anesthesia with isoflurane-fentanyl has been widely accepted as an anesthetic management for neurosurgery. This approach will, however, give a rather slow recovery, associated with a high frequency of PONV. A different technique is intravenous anesthesia with propofol-fentanyl. Propofol is associated with a shorter recovery time and less PONV. Unfortunately propofol during longer anesthesia, is associated with a higher cost. The aim of the study is to find out, if finishing an isoflurane-fentanyl anesthesia with propofol will lead to less PONV and a shorter recovery time.;Secondary Objective: No;Primary end point(s): The degree of postopeative pain and PONV is evaluated by Visual Analog Scale (VAS), a validated instrument. The recovery time in the two groups will be compared. | — |
Countries
Sweden
Outcome results
None listed