Depth of anaesthesia. Consumption of volatile anaesthetic agent. MedDRA version: 8.1 Level: LLT Classification code 10018060 Term: General anaesthesia
Conditions
Interventions
Trade Name: Catapres
Product Name: Clonidine
Product Code: N/A
Pharmaceutical Form: Solution for injection
INN or Proposed INN: CLONIDINE
CAS Number: 4205907
Current Sponsor code: Medway NHS Trust
Oth
Sponsors
Medway NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients having a general anaesthetic for a general surgical or orthopaedic procedure. The surgical procedure should last no longer than 2 hours. Aged between 18 and 70 years. ASA grading as 1 or 2. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Age 70 years. Beta blocker treatment. ASA grading of > 2. Raynaud's syndrome. Peripheral vascular disease. Depression. Hypersensitivity to clonidine. Sick sinus syndrome. AV block. Bradycardia < 50/min at rest. Congestive heart failure. Acute myocardial infarction in the past. Pregnancy. Breast feeding. Systolic BP < 100 mmHg. Renal or hepatic disease. Patient taking medication known to alter MAC of desflurane.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To see if the use of intravenous clonidine, given at induction of general anaesthesia, decreases the consumption of desflurane (a routinely used volatile anaesthetic agent). ;Secondary Objective: Nil;Primary end point(s): Reduction in desflurane consumption. | — |
Countries
United Kingdom
Outcome results
None listed