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A comparison of the analgesic efficacy of oral and intravenous paracetamol (perfalgan) in a day case setting - Oral versus IV paracetamol

A comparison of the analgesic efficacy of oral and intravenous paracetamol (perfalgan) in a day case setting - Oral versus IV paracetamol

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
EU CTR
Registry ID
EUCTR2006-002208-32-GB
Enrollment
Unknown
Registered
2006-09-18
Start date
2006-08-14
Completion date
Unknown
Last updated
2012-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

We will perform a double blind randomised comparison of oral paracetamol versus intravenous paracetamol (Perfalgan) in patients undergoing knee arthroscopy in a day surgery setting.

Interventions

Trade Name: Perfalgan Product Name: Intravenous (IV) paracetamol Pharmaceutical Form: Solution for infusion INN or Proposed INN: PARACETAMOL CAS Number: 103902 Concentration unit: mg/ml milligram(s)/m

Sponsors

York Hospital NHS Trust
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All patients on the list for day case knee arthroscopy aged between 18 to 60 years and weighing between 50 to 90 kg will be eligible for the study. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Age 60 years, ASA 3 or 4 (American society of anaestesiologist classification - ASA 3 & 4 are sicker patients than ASA 1 & 2), known allergy to paracetamol, patients who had paracetamol in the last 12 hours, pregnant or breast feeding women, history of complete non-responsiveness to acetaminophen, inflammatory bowel disease, chronic pain patients, arthroscopies related to infection (where surgeon would not instil local anaesthetic), bilateral arthroscopies.

Design outcomes

Primary

MeasureTime frame
Main Objective: We will perform a double blind randomised comparison of oral paracetamol versus intravenous paracetamol (Perfalgan) in patients undergoing knee arthroscopy in a day surgery setting. The main purpose of the trial will be to compare the analgesic effects of oral and intravenous paracetamol.;Secondary Objective: To note any side effects of using Perfalgan;Primary end point(s): Postoperative pain assessed by Visual Analogue Scale (VAS) scores and Verbal Rated Scale (VRS) scores during rest and during movement. Rescue analgesia required.—

Countries

United Kingdom

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026