Influenza in children [positive rapid diagnostic test (QuickVue influenza test)confirmed by influenza PCR] Infants and young children shed the influenza virus for longer periods than adults, duration of shedding occurring anywhere from up to 2-3 weeks as opposed to young adults who shed the virus for less than a week when serial viral cultures are performed.
Conditions
Interventions
Trade Name: Paracetamol (acetaminophen)
Pharmaceutical Form: Oral suspension
Trade Name: Ibuprofen (Nurofen)
Pharmaceutical Form: Oral suspension
Sponsors
Hammersmith Hospital NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Any infant or child presenting to the paediatric ambulatory unit with a history of one or more of the following conditions for less than 3 days (72hours) is eligible for recruitment. • Acute upper respiratory tract infections which include: colds, sinusitis, pharyngitis (red sore-throat), tonsillitis (inflamed tonsils) and acute otitis media • Acute lower respiratory tract illnesses which include: croup, tracheitis, bronchiolitis (wheeze under the age of 12-months), viral induced wheeze, asthma (history of atopy) and pneumonia • Any seizure: febrile and non-febrile • Any acute febrile gastroenteritis without rebound tenderness or guarding • Apnoea or any life-threatening event in infants under 12-months of age • Any acute febrile illness (temperature = 38.0C). • Parents should be fluent and literate in English • Parents are able and willing to adhere to the procedures stated in the protocol Are the trial subjects under 18? yes Number of subjects for this age range: F.1.2 Adults (18-64 years) no F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: • Inclusion criteria not met • Collection of a nasal secretion sample is medically contraindicated, e.g., child with recent nasopharyngeal surgery • Those with a fever and a known non-respiratory viral illness. • Children requiring admission • Allergic to ibuprofen or paracetamol • Any underlying chronic illness which requires the long term use of antipyretics and other analgesics such as acetaminophen and NSAID. • High risk medical conditions for influenza except for asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To determine if there is a difference in the duration of influenza virus shedding in children with influenza who are given acetaminophen compared to those given ibuprofen ;Secondary Objective: To determine if there is a difference in the time to alleviation of symptoms in children with influenza who are given acetaminophen or ibuprofen ;Primary end point(s): Primary endpoint Measures • Duration of viral shedding • Sequential viral loads | — |
Countries
United Kingdom
Outcome results
None listed