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Analgesia provided by intravenous paracetamol compared with intravenous morphine, for pain secondary to islolated limb trauma, in the emergency department: a pilot randomised controlled trial - Intravenous paracetamol compared with intravenous morphine for pain in the emergency department

Analgesia provided by intravenous paracetamol compared with intravenous morphine, for pain secondary to islolated limb trauma, in the emergency department: a pilot randomised controlled trial - Intravenous paracetamol compared with intravenous morphine for pain in the emergency department

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTR
Registry ID
EUCTR2006-001478-25-GB
Enrollment
60
Registered
2007-08-01
Start date
2007-09-12
Completion date
Unknown
Last updated
2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate to severe pain caused by limb trauma MedDRA version: 8.1 Level: LLT Classification code 10033371 Term: Pain

Interventions

Trade Name: Perfalgan Pharmaceutical Form: Intravenous infusion INN or Proposed INN: PARACETAMOL CAS Number: 103902 Concentration unit:

Sponsors

University Hospitals Bristol NHS Foundation Trust
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Isolated limb trauma requiring emergency department attendance Moderate to severe pain, with pain score of 7 or more out of 10 Age >16 and 50kg Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Chest pain GCS 20 weeks Breast feeding Patients requiring an immediate limb-saving procedure Age 65 years Patients in extreme distress who are unable to consent Communication difficulties (foreign language, prior confusion) preventing informed consent or co-operation with pain scoring

Design outcomes

Primary

MeasureTime frame
Main Objective: In this non commercial pilot study we aim to compare the effect of iv paracetamol with iv morphine in patients with moderate to severe pain attending the emergency department.; Secondary Objective: Occurrence of adverse events (local reaction, nausea, respiratory depression, hypotension, decreased GCS ) ;Primary end point(s): Pain scoring as measured by the visual analogue pain scale.—

Countries

United Kingdom

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026