Recurrent urinary tract infections
Conditions
Interventions
Product Name: Trimethoprim
Pharmaceutical Form: Coated tablet
INN or Proposed INN: Trimethoprim
Current Sponsor code: 2006GU01
Concentration unit: mg milligram(s)
Concentration type: equal
Concentrati
Sponsors
University of Dundee
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Community dwelling older women (aged 45 years or over) with at least 2 antibiotic treated UTIs or episodes of cystitis in the previous 12 months Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Previous urological surgery, stones or anatomical abnormalities or urinary tract; urinary catheter; diabetes mellitus; immunocompromised; pyelonephritis; severe renal impairment; blood dyscrasia; symptomatic UTI at baseline; cognitive impairment precluding informed consent; resident in institutional care; on longterm antibiotic therapy; on warfarin therapy; regular cranberry consumers; unwilling to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To establish the relative effectiveness of cranberry product compared to low dose trimethoprim (100mg daily) in the prevention of urinary tract infections (UTIs) in older women with recurrent infections;Secondary Objective: To assess the relative impacts on the gut microflora and antimicrobial resistance of cranberry product and low dose trimethoprim in older women To establish the acceptability of and adherence to both cranberry product and low dose trimethoprim;Primary end point(s): Time to first recurrence of UTI | — |
Countries
United Kingdom
Outcome results
None listed