double blind crossover compariosn of diuretics in young patients with low-renin hypertension - Glory 2

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2006-000637-35-GB

Enrollment

Registered

2006-05-03

Start date

2006-07-07

Completion date

Unknown

Last updated

2020-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low-renin hypertension

Interventions

Trade Name: Bendroflumethiazide Product Name: Bendroflumethiazide Pharmaceutical Form: Tablet Trade Name: Amiloride Product Name: Amiloride Pharmaceutical Form: Tablet Trade Name: Frusemide Product

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Aged 18-45 Male or Female Hypertnesive - 3 clinic SBP > = 140mmhg; 3 Clinic DBP > 90mmhg; or ABPM or home BP = > 130 (SBP) or 85 (DBP) Plasma renin = =65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Documented history of gout abnormal renal function (both elevated serum creatinine and reduced creatinine clearance) SBP > 170 mmHg or DBP > 110 mmHg despite treatment with permitted background drugs.

Design outcomes

Primary

Measure	Time frame
Main Objective: To determine whether low-renin (ie, salt sensitive)hypertension at a young age is caused by the kidneys hanging onto too much salt as a result of an overactive salt pump in the kidney. The Kidneys have four different salt pumps, and each is blocked by a different tye of diuretic (salt-losing tablet). If one out of the four is overactive, we would expect patients to respond much better to one diuretic than to the alternatives-rather than responding equally well to all the available types of diuretics.;Secondary Objective: To determine the genetic mutations responsible for the low renin hypertension.;Primary end point(s): To determine the best diuretic treatment for low-renin patients with high blood pressure	—

Measure

Time frame

Main Objective: To determine whether low-renin (ie, salt sensitive)hypertension at a young age is caused by the kidneys hanging onto too much salt as a result of an overactive salt pump in the kidney. The Kidneys have four different salt pumps, and each is blocked by a different tye of diuretic (salt-losing tablet). If one out of the four is overactive, we would expect patients to respond much better to one diuretic than to the alternatives-rather than responding equally well to all the available types of diuretics.;Secondary Objective: To determine the genetic mutations responsible for the low renin hypertension.;Primary end point(s): To determine the best diuretic treatment for low-renin patients with high blood pressure

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Countries

United Kingdom

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026