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Comparison of the vasoreactivity and endogenous NO production between the left and right internal mammary 6 months after bypass surgery with the injection of substance P and exogenous nitric oxide. - substance P and NO production

Comparison of the vasoreactivity and endogenous NO production between the left and right internal mammary 6 months after bypass surgery with the injection of substance P and exogenous nitric oxide. - substance P and NO production

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
EU CTR
Registry ID
EUCTR2006-000353-21-BE
Enrollment
10
Registered
2006-05-02
Start date
2006-05-29
Completion date
Unknown
Last updated
2025-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

We observe a higher FFR in the RITA then in the LIMA 6 month after CABG (Glineur D, Resistance to flow of arterial Y-grafts 6 months after coronary artery bypass surgery.Circulation. 2005 Aug 30

Interventions

Product Name: substance P Product Code: substance P Pharmaceutical Form: Powder and solvent for solution for injection INN or Proposed INN: Substance P C-061 Current Sponsor code: Substance P Other

Sponsors

Cliniques Universitaire St Luc
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: - CABG 6 months before systhematic angiogram - no tortuosity of the graft. - no stenosis at the coronary anastomosis Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: - Patient symptomatic of recurent myocarial ischemia - Effort test + - Anatomic difficulty of graft catheterisation.

Design outcomes

Primary

MeasureTime frame
Main Objective: Measure the endogenous NO production in the LIMA, RIMA, SVG 6 months after CABG;Secondary Objective: Observe differences in vasodilatation between these 3 grafts with the maximal endothelium induced vasodilatation (substance P), and with a maximal media induced vasodilatation (exogenous NO).;Primary end point(s): - No production by each graft. - Degree of Vasodilatation for each graft—

Countries

Belgium

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026