18 healthy male volunteers Age 18-35 yrs., nonsmokers
Conditions
Interventions
Product Name: L-NMMA · AcOH/C-020
Pharmaceutical Form: Intravenous infusion
INN or Proposed INN: NG-monomethyl-L-arginine
Concentration unit: mg/kg milligram(s)/kilogram
Concentration type: equal
Conc
Sponsors
Department of Clinical Pharmacology
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Men aged between 18 and 35 years, nonsmokers. Body mass index between 15th and 85th percentile (Must et al. 1991) Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant. Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant. Normal ophthalmic findings, ametropy =65 years) F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study. Treatment in the previous 3 weeks with any drug. Symptoms of a clinically relevant illness in the 3 weeks before the first study day. History of hypersensitivity to the trial drug or to drugs with a similar chemical structure. History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with, distribution, metabolism or excretion of study drugs. Blood donation during the previous 3 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Optic nerve head pressure-flow relationship ;Secondary Objective: ;Primary end point(s): | — |
Countries
Austria
Outcome results
None listed