Anesthesia
Conditions
Sponsors
University Hospital Ghent
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 18-65 years, scheduled for surgery requiring an arterial line to measure blood pressure and blood sampling for standard clinical practice (after normal Allan’s test ). Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Weight less than 70% or more than 130% of ideal body weight, neurological disorder, and recent use of psycho-active medication, including alcohol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Secondary Objective: ;Primary end point(s): Validation of the predicted propofol plasma concentration by the pharmacokinetic model using measured propofol plasma concentration. The model is accurate if the difference between the predited and the measured concentration is less than 25 % at a given time point.;Main Objective: To investigate if the calculated propofol plasma concentrations using the model published by Schnider et al. predicts accurately the measured plasma concentration of propofol during the first 5 minutes after a bolus dose given in 10 seconds or 3 minutes. | — |
Countries
Belgium
Outcome results
None listed