The study is carried out on patients at our Hospital, being treated with therapeutic hypothermia after cardiac arrest. The aim of the study is to tell if standard fluid therapy (RingerAC) leads to a different contain of oedema, compared to those pasiente reciving HyperHAES. We state the level of oedema both subcutaneous and intracerebral. We also study if these fluid therapies have a different effect concerning deaths, survivours etc.
Conditions
Interventions
Trade Name: HyperHAES
Product Name: HyperHAES
Pharmaceutical Form: Intravenous infusion
Trade Name: Ringer Acetat solution
Product Name: Ringer Ac
Pharmaceutical Form: Intravenous infusion
Sponsors
Dept. of Anaesthesia and Intensive Care, Haukeland University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patients admitted to this trial have to been exposed to a cardiac arrest, being vitnessed by their family, bystanders etc. The patiens also have to recive advanced CRP within 15 min. after their heart stopped. Return of spontanous circulation has to be stated within 60 minutes after the event. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Patiens suffering from severe life-threatening deseases like cancer com. met, etc. will be excluded. They who are younger than 18 years, or older than 80 years will also be excluded, as well those who have recived more than 2000 ml of intravenous fluid before admitted to our hospital. All other causes to the cardiac arrest than the cardial, like hypoxi, intoxocation ect, will be ruled out.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Secondary Objective: Secondary objectives are to state the level of oedema in their brains, (using MRI) and level of oedema subcutaneous.(Wicks`method). We also register the total amount of days in the ICU, the length of the intrahospital stay ect, the rate of adverse effects like infections ect.;Primary end point(s): The primary end points are the number of deaths and survivours in the two groups. Furthermore will the cognitive score after 12 months, be classified as a primary end point.;Main Objective: The main objective is to study different effects on rate of death, and the patients need for help/ward afterwards. We also perform a cognitive score of all these patiens a year after their cardiac arrest. | — |
Countries
Norway
Outcome results
None listed