Study on the pharmacodynamic interactions between propofol and sevoflurane during induction of anesthesia.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2005-004632-40-BE

Enrollment

Registered

2006-02-08

Start date

2005-11-25

Completion date

Unknown

Last updated

2014-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Interventions

Trade Name: Diprivan Product Name: Diprivan Pharmaceutical Form: Emulsion for infusion INN or Proposed INN: Propofol CAS Number: 2078-54-8 Concentration unit: mg/ml milligram(s)/millilitre Concentrati

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: American Society of Anesthesia class I and II patients 18-60 years Scheduled for surgery under general anesthesia Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Weight less than 70% or more than 130% of ideal body weight neurological disorder diseases involving the cardiovascular system (hypertension, coronary artery disease, prior AMI, any valvular and/or muscular disease involving decrease of the ejection fraction, arrhythmias, which are either symptomatic or require continuous medication/pacemaker/AICD) pulmonary disease including asthma, severe COPD, ... Gastric diseases including reflux Endocrinological diseases recent use of psycho-active medication, including alcohol

Design outcomes

Primary

Measure	Time frame
Main Objective: To investigate the pharmacodynamic interaction between propofol and sevoflurane.;Secondary Objective: ;Primary end point(s): Pharmacodynamic clinical effects: * hypnotic (as measured by computerised EEG) * analgesic (movement in response to different clinically relevant noxious stimuli)	—

Countries

Belgium

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026