A comparison of Helium-oxygen mixture (Heliox) with an oxygen-air mixture in reducing the work of breathing during weaning from mechanical ventilation. - Heliox and weaning

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2005-003612-30-GB

Enrollment

Registered

2005-10-25

Start date

2005-11-23

Completion date

Unknown

Last updated

2020-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients admitted to the intensive care unit who are in the recovery phase of their illness and are weaning from mechanical ventilation.

Interventions

Trade Name: Heliox21 Product Name: Heliox21 Product Code: n/a Pharmaceutical Form: Inhalation gas

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient will be defined as ready for weaning with CPAP if Failed a spontaneous breathing trial Pressure support ventilation =65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Inadequate analgesia Pregnancy Participation in other intervention trials in the past 30 days Refusal of consent from the patient or assent from the next of kin

Design outcomes

Primary

Measure	Time frame
Main Objective: This is a study to look at whether breathing Helium (which being much lighter than air is easier to breathe) and oxygen makes breathing easier for patients, and therefore enables them to be helped off the support provided by breathing machines (ventilator) in their recovery phase in the intensive care unit.;Secondary Objective: To measure a number of physical signs in the patient such as heart rate, rate of breathing and to see if breathing the Helium-oxygen mixture makes breathing more easy.;Primary end point(s): The primary endpoint will be CO2 production, a recognised measure of work of breathing during weaning.	—

Measure

Time frame

Main Objective: This is a study to look at whether breathing Helium (which being much lighter than air is easier to breathe) and oxygen makes breathing easier for patients, and therefore enables them to be helped off the support provided by breathing machines (ventilator) in their recovery phase in the intensive care unit.;Secondary Objective: To measure a number of physical signs in the patient such as heart rate, rate of breathing and to see if breathing the Helium-oxygen mixture makes breathing more easy.;Primary end point(s): The primary endpoint will be CO2 production, a recognised measure of work of breathing during weaning.

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Countries

United Kingdom

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026