Tunnelled haemodialysis catheter related infection. These infections are common (approximately 2-7 infections per 1000 catheter days) in patients on haemodialysis
Conditions
Interventions
Product Code: Antibiotic Line Lock(Vancomycin,Gentamicin,Heparin
Pharmaceutical Form: Solution for injection
Pharmaceutical form of the placebo: Injection*
Route of administration of the placebo: Intr
Sponsors
Wirral Hospitals NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All incident patients requiring insertion of a tunnelled haemodialysis line for haemodialysis. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: 1. Pateints on prolonged courses of antibiotics (oral or parenteral) i.e. for greater than 2 weeks. 2. Patients with a known allergy to vancomycin or gentamicin. 3. Patients known to suffer from heparin induced thrombocytopenia. 4. Patients who are pregnant or plan to become pregnant. 5. An inability to provide informed consent to participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To determine whether the use of the antibiotic line lock solution from catheter insertion is associated with a reduction in catheter related infection. The primary outcome measure is time in days to catheter related infection.;Secondary Objective: To assess the effects of this intervention on serum albumin, haemoglobin, erythropoietin requirements and hospital admissions.;Primary end point(s): Time in days from insertion of tunnelled haemodialysis catheter to first catheter related infection. | — |
Countries
United Kingdom
Outcome results
None listed