Patient scheduled for a primary total hipreplacement need postoperativ pain treatment. Morphine has side-effects: nausea, vomiting, sedation and dizziness. These sideeffekts are of couse unpleasant for the patients and sometimes keep them in hospital for a longer time than needed.
Conditions
Interventions
Trade Name: Lyrica
Pharmaceutical Form: Capsule*
Pharmaceutical form of the placebo: Capsule*
Route of administration of the placebo: Oral use
Trade Name: Forticontin
Pharmaceutical Form:
Pharmaceut
Sponsors
Dept. of Anaestesiology, University hospital in Glostrup
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients scheduled for a total hipreplacement, between the age of 55 and 75, ASA 1-3 and with a BMI between 18 and 35. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Patients who 1. are unable to cooperate 2. does not speak danish 3. has allergy for the drugs used in the trial 4. has drug and medicin abuse 5. epilepsi 6. medicaly treated diabetes 7. known kidney disease 8. daily use of anagesia - apart from NSAID, COX2 and paracetamol 9. treatment with antidepressives
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To improve the postoperative pain treatment for patients, who have had done a total hipreplacement, by using a new combination of secondary analgesics, and thereby hopefully minimizing there need for morphine postoperatively.;Secondary Objective: To see if the well-known analgesic effect og pregabalin, dexametason and paracetamol can act synergistically in patients how have had done a total hipreplacement.;Primary end point(s): The total amount of morphine needed postoperatively from 0-4 h, and 0-24h, administered by patient controlled pain treatment. | — |
Countries
Denmark
Outcome results
None listed