Type Two Diabetes Mellitus
Conditions
Sponsors
Greater Glasgow NHS Health Board / University of Glasgow co-sponsorship
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Type II diabetes of less than 5 years' duration treated with diet, metformin, thiazolidinediones or a combination of above Age > 40 years Normal full Bruce protocol exercise tolerance test Favourable temporal bony window Stable glycaemic control (HbA1c =65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: >70% extra-cranial internal carotid artery stenosis Known coronary arterial disease Significant co-morbidity Contra-indication to or indication for administration of allopurinol Concurrent azathioprine or 6-mercaptopurine therapy Insulin or sulphonylurea therapy Serum creatinine concentration greater than 250 micromoles per litre
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: The aim of the proposed program is to explore the mechanistic basis of impaired cerebrovascular nitric oxide bioavailability in patients with diabetes and to identify whether the observed abnormality can be reversed with pharmacological intervention using the xanthine oxidase inhibitor allopurinol.;Secondary Objective: ;Primary end point(s): The variable used for comparison between treatments will be the change in ICA flow (area under flow / time curve) induced by the L-NMMA infusion. | — |
Countries
United Kingdom
Outcome results
None listed