This is a volunteer study in healthy volunteers.
Conditions
Interventions
Pharmaceutical Form:
Pharmaceutical form of the placebo: Intravenous infusion
Route of administration of the placebo: Intravenous use
Pharmaceutical Form:
Pharmaceutical form of the placebo: Intrav
Sponsors
Department of Anaesthesia&Intensive Care B, Vienna Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: healthy volunteers (both male and female) ;age 19-40 yrs., body mass index between 15th and 85th percentile, drug free, right-handed. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Not healthy, oder than 40 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Secondary Objective: ;Main Objective: In this study the following hypotheses will be tested: ? Paracetamol has a dose dependant antihyperalgesic effect on primary and secondary hyperalgesia. ? Single dose tramadol has an antihyperalgesic effect on primary and secondary hyperalgesia. ? The combination of single dose tramadol with multidose paracetamol is superior to the effect of a single drug alone. ? This effect is dose dependent and more pronounced inversely to the dose of paracetamol.? ;Primary end point(s): ?heat pain perception threshold (HPPT) in the inflamed area (primary hyperalgesia) . | — |
Countries
Austria
Outcome results
None listed