Alcohol dependent patients
Conditions
Interventions
Trade Name: Cycloserine
Product Name: cycloserine
Pharmaceutical Form: Capsule*
Pharmaceutical form of the placebo: Capsule*
Route of ad
Sponsors
University of Bristol
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Alcohol dependence, abstinent [>2 weeks], aged 20-60, Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Major psychiatric morbidity, current or history of, e.g. psychosis, substance misuse or dependence [other than alcohol, nicotine], clinically significant abnormality on physical examination or investigation, pregnancy or breast-feeding. taking disulfiram, acamprosate or naltrexone.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To investigate whether D-cycloserine can reduce craving for alcohol in alcohol dependent individuals in response to salient cues.; Secondary Objective: To see if attential bias to alcohol cues predicts cue reactivity, and whether this moderates the effect of cycloserine on cue reactivity. ;Primary end point(s): Reduction in subjective and objective measures of craving. | — |
Countries
United Kingdom
Outcome results
None listed