Awake fibre optic intubation is an anaesthetic technique used to intubate patients with a difficult to manage airway. It s a procedure by which a tracheal tube is inserted in a patients trachea while the patient is awake. In fact, most patients are not totally awake but are more commonly sedated during this procedure. We want to compare the efficacy and safety of remifentanil with propofol for awake fibreoptic intubation.
Conditions
Interventions
Trade Name: Propofol
Product Name: Propofol
Pharmaceutical Form: Emulsion for infusion
INN or Proposed INN: propofol
Concentration unit: mg/ml milligram(s)/millilitre
Concentration type: equal
Concent
Sponsors
Oxford Radcliffe Hospitals NHS trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient inclusion Criteria: * ASA I-III patients requiring awake fibre optic intubation. * ASA- American society of Anesthesologist's classification of a patients physical status Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Patient exclusion Criteria: Age ASA 3 Unstable ward observations( acutely ill) Inability to communicate effectively
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Awake fibreoptic intubation is a technique which requires some form of sedation and/or analgesia to make it more acceptable to the patient.Both propofol a short acting intravenous anaesthetic drug and remifentanil, an intravenous opiate with some sedative properties are used in this context.The main aim of the study is to compare remifentanil target controlled infusion with propofol target controlled infusion for sedation and anxiolysis during an awake fibreoptic condition . This study is not designed to test a particular drug, rather to compare two drugs which are already in use for this purpose with the aim to test if one drug is better than the other for sedation of patients undergoing am awake fibre-optic intubation ;Secondary Objective: ;Primary end point(s): PATIENT SEDATION SCORING SYSTEM MODIFIED STEWARD SCORE CONSCIOUSNESS (0-4) 4-fully awake, eyes open, conversive 3-lightly asleep ,eyes open intermittently 2-eyes open on command 1-response to ear pinching 0-no response AIRWAY (0-4) 3-opens mouth, coughs on command 2-opens mouth, clear airway, weak cough 1-airway obstruction relieved by head extension 0-airway obstruction needing jaw retraction/oropharyngeal airway ACTIVITY( 0-3) 2-raising arm on command 1-non purposeful movement 0-no movement DISCOMFORT SCORE(0-3) 0-no discomfort 1-probable mild discomfort, no patient resistance 2-restless patient, minimal patient resistance 3-restless patient, severe patient resistance DIFFICULTIES DURING ENDOSCOPY SCORE (0-2) 0-absent 1-present but did not interfere with endoscopy 2-present and was hindrance to endoscopy | — |
Countries
United Kingdom
Outcome results
None listed