Women scheduled for abdominal hysterectomy needs postoperative pain treatment, i.e. morphine. Morphine has side-effects: nausea, vomiting, sedation and dizziness. These side-effects are of course unpleasant for the patients and sometimes keep them in hospital for a longer time than needed.
Conditions
Interventions
Product Name: pregabalin
Pharmaceutical Form: Capsule*
Pharmaceutical form of the placebo: Capsule*
Route of administration of the placebo: Oral use
Product Name: Dexamethason
Pharmaceutical Form: In
Sponsors
Dept. of Anaestesiology, University hospital in Glostrup
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Women scheduled for abdominal hysterectomy, between the age of 18 and 75. ASA 1-2; and with a BMI: between 18 and 32. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Patients who: 1. are unable to cooperate 2. has cancer ovarian 3. does not speak Danish 4. has allergy for drugs used in the trial 5. has drug and medicine abuse 6. epilepsy 7. diabetes treated with medicine 8. chronic pain condition 9. daily use of antacids or analgesic 10. Known kidney disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To improve the postoperative pain treatment for patients with an abdominal hysterectomy, by using a new combination of secondary analgesics, and thereby hopefully minimizing there need for morphine postoperatively.;Secondary Objective: To see if the well-known analgesic effect of pregabalin, dexametason and paracetamol can act synergistically in patients who becomes an abdominal hysterectomy.;Primary end point(s): The total amount of morphine needed postoperatively from 0 – 4 h, and 0 – 24 h, administered by patient controlled pain treatment. (PCA). | — |
Countries
Denmark
Outcome results
None listed