Ischaemia reperfusion injury following elective abdominal aortic aneurysm repair. This occurs when muscle or organ is subjected to an ischaemic insult with associated damage followed by reperfusion with the production of oxygen free radicals which further damage local and also distant tissues. This condition occurs in many conditions including myocardial infarction, peripheral vascular disease, and various medical procedures including repair of abdominal aortic aneurysm.
Conditions
Interventions
Trade Name: Lipitor 80mg
Product Name: Atorvastatin 80mg
Product Code: 756111000001109
Pharmaceutical Form: Coated tablet
Pharmaceutical form of the placebo: Capsule*
Route of administration of the pl
Sponsors
Hull and East Yorkshire Hospitals NHS Trust
University of Hull
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients scheduled for elective abdominal aortic aneurysm repair. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: 1/ Patients already on statins (3-hydroxy-3-methylglutaryl coenzyme A {HMG CoA} reductase inhibitors). 2/ Patients with unilateral or bilateral lower limb amputations. 3/ Participation in other trials with investigational treatment for ischaemia reperfusion injury. 4/ Inability to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Investigating systemic and cellular responses to ischaemia reperfusion injury after pre-operative statin use for a month in comparison to double blinded placebo users.;Secondary Objective: ;Primary end point(s): Blood and urine sampling 24 hours after completion of aneurysm repair. | — |
Countries
United Kingdom
Outcome results
None listed